Mandurino-Mirizzi A, Cornara S, Somaschini A, et al. - Researchers conducted this study with the aim to examine the correlation of elevated serum uric acid (eSUA) with short- and long-term mortality, as well as with inflammatory response, in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI). Blood samples obtained at the time of admission and at 24 and 48 hours after pPCI were assessed for the inflammatory biomarkers C-reactive protein, neutrophil count and neutrophil to lymphocytes ratio. A total of 2,369 patients with STEMI were considered. Analysis revealed correlation of elevated serum uric acid with higher short- and long-term mortality and with a greater inflammatory response after reperfusion in patients with STEMI treated with primary PCI. Observations suggest a threshold effect for SUA levels (≥ 6.7 mg/dl) on mortality after STEMI.