van der Kaaij RT, et al. - In esophageal adenocarcinoma patients scheduled for chemoradiotherapy followed by surgery, researchers examined the link between carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19-9 levels at diagnosis and survival and early treatment failure (disease recurrence or death within 1 year after surgery). From a retrospectively collected database, patients were chosen if both CEA and CA19-9 levels were assessed prior to treatment initiation. In this patient cohort treated with curative intent, findings revealed a significant correlation between elevated pretreatment CEA and CA19-9 levels and both early treatment failure and decreased overall survival. With the help of CEA and CA19-9, high-risk patients might be detected before beginning intensive locoregional therapy.