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Elevated eosinophils as a feature of inflammation associated with hypertension in virally suppressed people living with HIV

Journal of the American Heart Association Feb 26, 2020

Masenga SK, Elijovich F, Hamooya BM, et al. - Whether chronic inflammation may contribute to hypertension in people living with HIV (PLWH), was investigated in this study including a cohort comprising 70 PLWH (44% hypertensive) on a long-term single antiretroviral therapy regimen. The levels of inflammatory cytokines, including tumor necrosis factor-α receptor 1, interleukin-6, interleukin-17, interleukin-5, intercellular adhesion molecule 1 and macrophage inflammatory protein-1α, were found to be higher among hypertensive PLWH. The circulating eosinophils continued to be significantly related to hypertension, following adjustment for age, gender, and fat mass index. Considering these outcomes, experts evaluated the link of eosinophils and hypertension in 2 cohorts including 50 and 81,039 similar HIV-negative individuals; although a link of eosinophil count with prevalent hypertension was evident, this association was abrogated by body mass index. A unique linkage between immune status and cardiovascular physiological features in HIV infection was suggested.
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