Kawachi S, et al. - Because the utility of dynamic lung hyperinflation (DLH) after metronome-paced incremental hyperventilation (MPIH) for evaluation of pathophysiological impairment in patients with chronic obstructive pulmonary disease has been reported, researchers assessed the impacts of tiotropium and olodaterol on DLH following MPIH in the present analysis. The patients were administered tiotropium/olodaterol 5/5 μg inhalation solution (2.5/2.5 μg per actuation) using a soft-mist inhaler once a day. At both time points ie, prior to and following 8 weeks of treatment, the outcomes were compared. This study was completed by 33 patients. In this study, the combination of tiotropium and olodaterol effectively improved DLH following hyperventilation.