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Efficacy of intraoperative antiseptic techniques in the prevention of periprosthetic joint infection: Superiority of betadine

Journal of Arthroplasty Mar 18, 2019

Cichos KH, et al. - Researchers examined the data to delineate the minimal inhibitory concentration (MIC), time to death for povidone-iodine (PI), chlorhexidine gluconate (CHG), and vancomycin (VANC) against multiple bacteria and also to determine the time to death against bacteria methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus epidermidis, Haemophilus influenzae, Pseudomonas aeruginosa, Burkholderia cepacia, and Escherichia coli dried on titanium discs. They observed MIC, 1.56 μg/mL for VANC, 0.63% for PI and 0.0031% for CHG. They recorded the death of all 7 bacterial isolates by PI at all times tested whereas CHG failed to kill MRSA and B cepacia at 0- and 3-minute exposures.
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