Khan SF, Khan MU, Riaz H, et al. – In this umbrella review and evidence map, researchers assessed evidence regarding the impact of nutritional supplements and dietary interventions on mortality and cardiovascular outcomes in adults. Eligible studies included English-language, randomized controlled trials (RCTs), and meta-analyses of RCTs that evaluated the aforementioned relationship on all-cause mortality or cardiovascular outcomes—including death, myocardial infarction, stroke, and coronary heart disease. In all, 9 systematic reviews and 4 new RCTs were included, representing a total of 277 trials, 24 interventions, and 992,129 participants. A total of 105 meta-analyses were generated. According to findings, reduced salt consumption, omega-3 LC-PUFA use, and folate supplementation could decrease the risk for some cardiovascular outcomes in adults. However, combined calcium and vitamin D may increase the risk for stroke.