Yoshizumi Y, et al. - Researchers assessed the efficacy of the combination of vitrectomy with kallidinogenase for diabetic macular oedema (DME) in this prospective, randomized, multicenter study. They included logMAR visual acuity and central foveal thickness (CFT) before surgery and at 3, 6, 9, and 12 months after vitrectomy as the main outcome measurements. Data suggested significant improvement of visual acuity and CFT in both groups after vitrectomy for DME. Throughout the study period, significant improvement was seen only in patients treated with kallidinogenase.