Jung YH, Mamadjonov N, Lee HY, et al. - Since a previous report by experts has shown facilitation of restoration of spontaneous circulation by pralidoxime via potentiating the pressor effect of epinephrine, researchers investigated the optimal dose of pralidoxime during cardiopulmonary resuscitation as well as assessed the involvement of α-adrenoceptors in its pressor action. They randomly administered 1 of 3 doses of pralidoxime (40, 80, or 120 mg/kg) or saline placebo to 44 pigs during cardiopulmonary resuscitation, including epinephrine administration. Findings revealed improved restoration of spontaneous circulation rate, in a pig model of cardiac arrest, as a result of administration of pralidoxime at 40 mg/kg with epinephrine, this effect was brought about by causing an increase in coronary perfusion pressure. However, no improvement in coronary perfusion pressure or restoration of spontaneous circulation rate was induced by 120 mg/kg. The pressor effect of pralidoxime was not associated with α-adrenoceptors and was buffered by its vasodepressor action mediated by sympathoinhibition.