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Effects of caffeine intake on the biomechanical properties of the cornea: A placebo-controlled, double-blind, crossover pilot study in low caffeine consumers

Graefe's Archive for Clinical and Experimental Ophthalmology Jul 15, 2020

Jiménez R, Molina R, Redondo B, et al. - In the present study, the researchers sought to evaluate the short-term effects of caffeine intake on the biomechanical properties of the cornea, as well as its possible connection with the intraocular pressure (IOP), as measured by corneal visualization Scheimpflug technology (CorVis ST) in healthy individuals. Across two separate trials, 22 low caffeine consumers ingested either caffeine (4 mg/Kg) or placebo capsule. According to findings, intake of caffeine decreases the deformability of the cornea, with these changes being partially correlated with the increase in IOP. Such results suggest that when making clinical decisions based on the biomechanical properties of the cornea, exogenous factors such as consumption of caffeine should be taken into account.

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