Schiavon CA, et al. - In this randomized trial, researchers investigated the impact of bariatric surgery on 24-hour blood pressure (BP) profile, BP variability, and resistant hypertension prevalence in obese patients with grade 1 and 2 (using at least 2) antihypertensive drugs at maximal doses or > 2 at moderate doses. Overall, 100 patients were allocated to either Roux-en-Y Gastric Bypass (RYGB) combined with medical therapy or medical therapy alone for 12 months. Findings revealed that fewer antihypertensive classes were needed in the RYGB group vs the medical therapy alone, while the 24-hour BP profile (including nondipping status) was similar after 12 months. Following RYGB as compared with medical therapy, a lower average real variability of systolic nighttime BP was observed. At baseline, similar prevalence of resistant hypertension was observed, but it was significantly lower in the RYGB at 12 months.