Aronow WS, et al. - This random-effects direct frequentist meta-analyses investigated the effects of aripiprazole, quetiapine, risperidone, olanzapine, ziprasidone and brexpiprazole on QT interval in patients with mental disorders. Low quality evidence pointed out that aripiprazole (4 meta-analyses and 12 RCTs), brexpiprazole (1 systematic review and 4 RCTs) or olanzapine (5 meta-analyses and 20 RCTs) did not increase QT interval. Aripiprazole, brexpiprazole or olanzapine in licensed doses could be suggested in people with mental disorders and under treatment with atypical antipsychotic drugs, in order to avoid QT prolongation and reduce the risk of ventricular tachycardia.