Benfari G, et al. - Among prospectively enrolled patients with severe isolated aortic valve stenosis (AS), scheduled for aortic valve replacement (AVR), researchers intended to determine the markers of a favorable evolution of the left ventricular (LV) diastolic dysfunction (DD) at follow-up. Prior to surgery and at 12 months post-surgery, transthoracic echocardiography with DD evaluation was performed. At baseline, global LV longitudinal and circumferential strain, peak atrial longitudinal and contraction strain (PALS, PACS) were recorded. At the time of AVR, LV septal biopsy was performed to evaluate fibrosis. This study included 67 patients, with age 72 ± 8 years. Females comprised 66% of the sample. The participants had ejection fraction 61 ± 8%, E/e’ 13 ± 6, PALS 23 ± 7%. Following AVR for severe AS, a general improvement of LV diastolic function was reported. Findings revealed the association of baseline PALS, PACS, and LV fibrosis with DD and clinical outcome at follow-up; these parameters possibly cue a better diastolic response to the afterload correction.