Al-Qaissi A, et al. - In this prospective, parallel study, researchers examined the impacts of acute insulin-induced hypoglycaemia on endothelial microparticles (EMPs), novel surrogate markers of endothelial injury and dysfunction, in adults with and without type 2 diabetes. The study sample consisted of people with type 2 diabetes (n = 23) and controls (n = 22). The associations between peak elevations (% rise from 0 minutes after hypoglycaemia) within 240 minutes of insulin-induced hypoglycaemia in the case of CD31⁺, CD54⁺, CD62-E⁺, CD105⁺ and CD142⁺ and diabetes status indicate that the assessment of a panel of EMPs would identify a hypoglycaemic event in this population within this period. The higher overall responses over time (AUCs) for apoptosis-induced CD31⁺ and CD105⁺ EMPs indicate that hypoglycaemia exerts greater endothelial stress in type 2 diabetes.