Effect of statins on fasting glucose in non-diabetic individuals: Nationwide population-based health examination in Korea
Cardiovascular Diabetology Dec 09, 2018
Kim J, et al. - Researchers evaluated 379,865 non-diabetic individuals from the National Health Screening Cohort who had ≥ 2 health screening examinations in Korea with fasting blood glucose levels measured in 2002–2013 to determine the impact of statin use on longitudinal changes in fasting glucose levels, given that a diabetogenic effect of statin therapy has been reported. They noted a significant association of more adherent and intensive use of statins with an increase in the fasting glucose of non-diabetic individuals. Also, a significant association of increase in fasting glucose was demonstrated by atorvastatin, rosuvastatin, pitavastatin, and simvastatin use. Moreover, albeit non-significant, they observed a trend toward an increased fasting glucose with the use of pravastatin, lovastatin, and fluvastatin. Overall, findings indicated the medication class effect of statins inducing hyperglycemia in this study population.
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