Williams C, et al. - Given that death and myocardial infarction (MI) both are reduced in relation to measurement of fractional flow reserve (FFR) to guide selection of lesions for percutaneous coronary intervention (PCI), vs angiographic guidance, in stable ischaemic heart disease (SIHD), but there is a lack of knowledge on whether the improved results are because of avoidance of stenting of physiologically insignificant lesions or are a by-product of placing fewer stents, so, researchers constructed a Monte Carlo simulation utilizing the PCI strata of the Bypass Angioplasty Revascularization Investigation 2 Diabetes study to determine the impact of random deferral of PCI on outcomes. They eliminated and substituted a randomly picked group of patients randomised to PCI by an equal number of randomly selected patients randomised to intensive medical therapy in order to simulate deferral. As per findings, in this simulation model, random deferral of PCI procedures in SIHD resulted in a progressive decrease in mortality/MI as the percentage of procedures deferred rose. It was also inferred that FFR-guided deferral of PCI may improve results as a consequence of placing fewer stents as well as be unrelated to the haemodynamic severity of lesions.