Sakima A, Arima H, Matayoshi T, et al. - Researchers analyzed randomized trials assessing MRA (mineralocorticoid receptor antagonists) impacts on arterial stiffness as well as on endothelial function. These studies were identified from PubMed and Cochrane CENTRAL (Cochrane Central Register of Controlled Trials). In 11 trials comprising 515 patients, MRA treatment decreased the pulse wave velocity (PWV) vs control, without heterogeneity. Experts found comparable impacts of MRA on carotid-femoral PWV and those on other forms of PWV. As per meta-regression analysis, MRA impacts on PWV were independent of blood pressure decrease associated with the treatment. Overall, MRA was shown to have beneficial impacts on PWV, augmentation index, and flow-mediated dilation.