Berninger MT, et al. - Authors evaluated the impact of local infiltration analgesia (LIA), peripheral nerve blocks, general and spinal anesthesia on early functional recovery and pain control in primary unicompartmental knee arthroplasty (UKA). In all groups, pain relief was comparable without clinically relevant differences except for a significant lower NRS score at rest in the LIA groups at day of surgery, while a significantly lower use of opioids was seen in patients with SP&EPI. Findings failed to state a clear clinically relevant benefit for LIA in UKA. Nonetheless, a safe and effective treatment option was offered by LIA comparable to the well-established conventional procedures.