Costa ML, Achten J, Knight R, et al. - A randomized clinical trial was performed to evaluate the outcomes in individuals who have incisions resulting from surgery for lower limb fractures related to major trauma and were treated with either incisional negative pressure wound therapy or standard wound dressing. Researchers recruited a total of 1,548 individuals aged 16 years or older who underwent surgery for a lower limb fracture caused by major trauma between July 7, 2016, and April 17, 2018, with follow-up to December 11, 2018. The use of incisional negative pressure wound therapy, compared with standard wound dressing, resulted in no significant difference in the rate of deep surgical site infection among individuals who underwent surgery for major trauma–related lower limb fractures. The outcomes do not confirm the use of incisional negative pressure wound therapy in this setting, although the event rate at 30 days was lower than expected.