Kim TE, et al. - Authors gauged the impact of green tea on the pharmacokinetics of digoxin, a typical probe drug of p-glycoprotein (p-gp). Findings suggested that the systemic exposure of digoxin, regardless of pretreatment of green tea catechins (GTC), was reduced by the coadministration of GTC. A significant reduction in the systemic exposure of digoxin was seen with the concomitant administration of digoxin and GTC vs digoxin alone: geometric mean ratios (GMR) and 90% confidence intervals (CI) of area under the concentration–time curve from time 0 to the last measurable time (AUClast) and Cmax were 0.69 and 0.72, respectively.