Tan ESJ, et al. - Researchers determined how cardiac resynchronization therapy (CRT) response and cardiovascular outcomes in Asian heart failure (HF) patients were influenced by diabetes mellitus (DM) in the Prospective Evaluation of Asian with CRT for Heart Failure study. Time to composite of HF-hospitalization and all-cause death was considered as the primary endpoint. The participants (n=161, age 66.7 ± 11.2 years, 22% females, mean QRS duration 154.3 ± 22.4 ms, 83% left bundle branch block) were observed for 3.3 ± 1.5 years. CRT responders and super-responders were 84 (52%) and 57 (35%) of the overall participants, respectively. The strongest predictor of event free survival was the extent of reverse remodeling after CRT. However, DM caused a reduction in reverse remodeling and induced end organ dysfunction, thereby affecting CRT recipients in a detrimental manner. Also, an independent link of DM with worsened clinical outcomes was found in Asian HF patients.