Wang S, Müller J, Goeder D, et al. - This study is done with 2,769 Veterans (58.7 ± 11.6 years) who had a maximal exercise test for clinical reasons, to determine the impact of beta blockade on exercise heart rate gradient (EHRG). Experts performed net reclassification improvement (NRI) to assess the effect of heart rate (HR) reserve, HR recovery and EHRG on all-cause death for patients with and without beta-blocker use. The deaths of 657 patients were reported during a mean follow up of 10.9 ± 4.1 years. Findings demonstrated the superiority of EHRG, vs both HR reserve and HR recovery, in predicting mortality, along with its ability in affording significant reclassification of risk but only in patients not receiving beta-blockers.