Suzuki A, et al. - In this retrospective cohort study, researchers assessed the impact of asymptomatic severe aortic stenosis (AS) on mortality late in life. They examined asymptomatic adults aged 80 and older (mean age 86 ± 4; N=1,060, n=569 women) with preserved left ventricular ejection fraction (LVEF; > 50%); 927 (87.5%) with no AS, 70 (6.6%) with nonsevere AS, and 63 (5.9%) with severe AS. Findings revealed a major impact of asymptomatic severe AS on prognosis, even in very old adults. In univariable analysis, asymptomatic severe AS was found to be significantly related to greater risk of all-cause mortality. Asymptomatic severe AS was identified as an independent predictor of all-cause mortality after adjustment for age, sex, LVEF, hypertension, dyslipidemia, diabetes, atrial fibrillation, chronic kidney disease, and coronary artery disease.