Machline-Carrion MJ, et al. - In this cluster randomized clinical trial involving 1,624 patients from 36 hospitals in three countries, researchers evaluated if a multifaceted quality improvement intervention can influence adherence to evidence-based therapies for acute ischemic stroke (AIS) and transient ischemic attack (TIA) patient care. Data revealed that hospitals in the intervention group had a composite adherence score of 85.3% for evidence-based performance measures, vs 77.8% in the control group, which was not statistically significant. Findings revealed that there was no significant increase in the composite adherence score for evidence-based therapies in patients with AIS or TIA due to a multifaceted quality improvement intervention. However, the intervention resulted in enhanced adherence to evidence-based therapies when using an all-or-none approach.