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Early repolarization in the inferolateral leads predicts the presence of vasospastic angina: A novel predictor in patients with resting angina

Coronary Artery Disease May 12, 2021

Ikeda H, Hasegawa K, Uzui H, et al. - Given a link between early repolarization and ventricular fibrillation has recently been noted in patients suffering from vasospastic angina (VSA), researchers sought to clarify if VSA can be predicted by the presence of early repolarization. They analyzed 286 patients (136 men) with clinically suspected VSA who received intracoronary provocation tests employing acetylcholine or ergonovine. Participants were split into a VSA group [n = 94, positive provocation test as induction of coronary arterial spasm (> 90% stenosis)] and a non-VSA group (n = 192). The presence of early repolarization (defined as a J-point elevation ≥ 0.1 mV from baseline in both or either of inferolateral leads) on baseline 12-lead ECG was seen in 39 patients (inferior leads, n = 27; inferolateral leads, n = 12). The VSA group, vs the non-VSA group, more frequently had early repolarization. Overall, early repolarization in patients with resting chest pain was identified as a predictor of VSA that could be especially associated with the inferior lead, higher amplitude, notched type and horizontal/descending ST segment.

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