Chen CJ, et al. - A series of 267 cases were reviewed between 1994 and 2015 who received curettage treatment and placement of a bone filler by the researchers in order to explicate that good functional results could be accomplished with curettage and bone filler, despite the type. Cases involved 18 autografts, 74 allografts, 121 bone graft substitute, and 54 polymethyl methacrylate (PMMA) of which the bulk of complications happened. A complication rate of 1.35%, 4.13%, 5.56% of an allograft, a bone graft substitute, and a PMMA, respectively, was noted. Other techniques did not generate any complications. Combination filling techniques PMMA + allograft and PMMA + bone graft substitute had sample sizes too inadequate for statistical comparison. Statistical comparison produced no notable variation between complications in any of the filling groups. Some have even argued that bone defects after curettage do not need bone filling for a good outcome. Nonetheless, by filling large bone defects, many structural or biologic advantages that help in earlier return to functionality can be presented. No notable variation in postoperative complication rates between allograft, bone graft substitute, and PMMA when contrasted at the researcher's institution and with literature values was observed. Although, one complication with a large defect filled with allograft, necessitating the following reconstruction using vascularized fibular graft was noticed. Taking everything into account, the bone graft substitute was concluded as a relevant alternative to other bone filling modalities.