Li P, Geng Z, Ladage VP, et al. - In this retrospective analysis involving 14,466 patients, researchers estimated risk factors correlated with early hypoglycemia (defined as ≥ 1 hypoglycemic event ≤ 6 months postindex) in Medicare Part D beneficiaries with type 2 diabetes starting basal insulin (BI) and its effect on adherence and persistence to treatment. For this investigation, they used a 5% sample of Medicare files from 2007–2013 to find those with type 2 diabetes starting BI from January 1, 2008 to December 31, 2012. To examine factors related to early hypoglycemia and BI adherence/persistence, multivariable logistic and Cox regression analyses were conducted. Within the first 6 months of BI treatment, 1,315 (9.1%) patients encountered hypoglycemia in this sample. Female sex, receipt of a low-income subsidy under Medicare Part D, high diabetes complication score index, and hypoglycemia during the baseline period were factors linked to early hypoglycemia. Investigators found that nearly 1 in 10 Medicare Part D beneficiaries encountered hypoglycemia within 6 months of BI initiation. Over 12- and 36-month follow-up, early hypoglycemia was linked to reduced adherence to BI treatment.