Liu Y, et al. - Researchers evaluated the relationship between levels of alkaline phosphatase (ALP) in early pregnancy and the incidence of large-for-gestational-age (LGA) neonates in pregnant women without gestational diabetes mellitus. For this study, 544 women and their biochemical parameters including serum ALP and demographic characteristics were collected in the 13-16th gestational week. This prospective cohort found that a significantly increased risk of LGA was related to higher serum concentrations of ALP in pregnant women with NGT, even it is in the normal reference range.