Mishima E, Sato E, Ito J, et al. - Using a cell-based assay, cytochrome P450 substrate compounds were screened in order to recognize drugs with antiferroptotic activity, examine the underlying mechanism and to recognize ferroptosis-causing radicals. Different US Food and Drug Administration–approved drugs and hormones that have antiferroptotic properties, like rifampicin, promethazine, omeprazole, indole-3-carbinol, carvedilol, propranolol, estradiol, and thyroid hormones were identified. However elevated lipid peroxyl radical levels could provoke ferroptosis onset, some drugs that scavenge lipid peroxyl radicals could aid in controlling ferroptosis-related disorders, such as AKI.