Yan J, et al. - This study was designed to examine the function and mechanism of miR-142-5p in metastasis of gastric cancer (GC). For this investigation, MiR-142-5p expression was detected in 101 GC samples by qRT-PCR and its clinical significance was statistically analyzed. The present data indicated that MiR-142-5p downregulation was significantly related to the recurrence and poor prognosis of GC. According to the findings obtained, the newly identified miR-142-5p-CYR61-Wnt/β-catenin axis partially illuminates the molecular mechanism of GC recurrence and represents a novel prognosis biomarker for GC.