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Does potentially inappropriate prescribing predict an increased risk of admission to hospital and mortality?: A longitudinal study of the ‘oldest old’

BMC Geriatrics Feb 03, 2020

Cardwell K, Kerse N, Hughes CM, et al. - Given the link of potentially inappropriate prescribing (PIP) with negative health results, including hospitalisation and death, researchers used data from LiLACS NZ (Life and Living in Advanced Age: a Cohort Study in New Zealand), which represents a longitudinal analysis of Māori (the indigenous population of New Zealand) and non-Māori octogenarians, to define the link of PIP with hospitalisations and mortality prospectively over 36-months observation span. In Māori, the prevalence of any PIP [ie, ≥ 1 PIM (potentially inappropriate medicine) and/or potential prescribing omission] was estimated to be 66% at baseline, 75% at 12-months and 72% at 24-months, the respective values at same time points in non-Māori were 62, 71 and 73%. Findings revealed an increased risk of hospitalisation and mortality in relation to PIP in this cohort. In the prediction of hospitalisations, omissions seemed more significant for Māori, and for mortality prediction, PIMs were more significant in non-Māori. Findings call for understanding prescribing results across and between population groups and also highlight the usefulness of prescribing quality evaluation.
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