Gong L, et al. - Considering the neuroimaging studies suggesting the association of anhedonia, a core feature of major depressive disorder (MDD), with dysfunction in reward and cognitive control processing, researchers explored how the reward network (β-network) and the cognitive control network (δ-network) are linked to biased anhedonia in MDD patients. A resting-state functional magnetic resonance imaging scan was performed on 68 MDD patients and 64 cognitively normal (CN) subjects. Initial findings demonstrated that anhedonia severity could be successfully predicted via an imbalance between β- and δ-network activity in MDD patients. The neural features of both the β- and δ-networks could be a fundamental mechanism that underlies anhedonia.