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Dispensation of antiretroviral therapy and methadone maintenance therapy at the same facility in a low-barrier setting linked to optimal adherence to HIV treatment

HIV Medicine Oct 08, 2019

Salleh NAM, Fairbairn N, Nolan S, et al. - Researchers investigated the link between dispensation of methadone maintenance therapy (MMT) and antiretroviral therapy (ART) at the same facility, across multiple low-barrier dispensing outlets, and achieving optimal adherence to ART among people who use illicit drugs (PWUD). From the AIDS Care Cohort to Evaluate Exposure to Survival Services study, a long-running study of a community-recruited cohort of HIV-positive PWUD, data were linked to comprehensive HIV clinical records in Vancouver, Canada—a setting of no-cost, universal access to HIV care. Data on 1,690 interviews of 345 ART- and MMT-exposed participants carried out between June 2012 and December 2017 were included. In the final multivariable model, greater odds of achieving ≥ 95% adherence were observed in correlation with MMT-ART dispensation vs non-dispensation at the same facility. As per marginal structural model, there were 1.48 greater odds of ≥ 95% adherence among participants who reported MMT-ART dispensation at the same facility relative to those who did not. Findings thereby emphasized the need for considering a simpler integrated approach with medication dispensation at the same facility in low-threshold settings.

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