Bozbeyoglu E, et al. - Researchers tested three- and four-variable formulas as tools to differentiate subtle ST-segment elevation (STE) due to anterior myocardial infarction (MI) from benign variant (BV) STE in a population of consecutive patients who were admitted with the diagnosis of acute anterior STEMI. After systematically reviewing electrocardiograms, only subtle ones were included. The control group was comprised of the first 200 consecutive patients with noncardiac chest pain. Relevant electrocardiographic parameters were measured. Findings implied reasonable sensitivity, specificity, and diagnostic accuracy of three- and four-variable formulas with recommended cutoffs in differentiating subtle STEMI with BV-STE. Although both perform well, higher sensitivity, specificity, and diagnostic accuracy was demonstrated by the four-variable formula, it should be the preferred tool for this purpose.