Gabel K, et al. - In adults with overweight or obesity and insulin resistance, researchers compared the impacts of alternate-day fasting (ADF) vs daily calorie restriction (CR) on body weight and glucoregulatory factors. They analyzed the data of insulin-resistant people (n = 43) who were part of a 12-month study comparing ADF (25% energy needs on “fast days”; 125% energy needs on alternating “feast days”) with CR (75% energy needs every day) and a control group regimen. Despite similar decreases in body weight, ADF may offer larger decreases in fasting insulin and insulin resistance in insulin-resistant participants vs CR according to this secondary analysis. It was noted that lean mass, visceral fat mass, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, blood pressure, C-reactive protein, tumor necrosis factor α, and interleukin 6 values were unchanged.