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Different clinical features of patients with pulmonary disease caused by various mycobacterium avium–intracellulare complex subspecies and antimicrobial susceptibility

International Journal of Infectious Diseases Sep 10, 2020

Chang CL, Chen LC, Yu CJ, et al. - Researchers investigated characteristics of the Mycobacterium aviumintracellulare complex pulmonary disease (MAC-PD) caused by distinct subspecies. From 2013–2015, they identified 144 patients with Mycobacterium avium pulmonary disease in three hospitals in Taiwan. Among these, 57 (39.6%), 37 (25.7%), 37 (25.7%), and 13 (9.0%) were infected with Mycobacterium intracellulare subspecies intracellulare (MIsI), M. avium subspecies hominissuis (MAsH), M. intracellulare subspecies chimaera (MIsC), and others, respectively. During the 2-year follow-up, spontaneous culture-negative conversion occurred in 22 (15.3%) patients while 15 (10.4%) exhibited radiographic progression. Patients with MAsH-pulmonary disease were characterized by younger age, a higher human immunodeficiency virus infection rate and a higher radiographic progression rate. The susceptibility rates to clarithromycin and inhaled amikacin were both 98.6% among all MAC species, and the lowest rate of resistance to moxifloxacin was observed for MAsH .

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