Rymer JA, Webb L, McCall D, et al. - When prescribed at the labeled dose, direct oral anticoagulants (DOACs) are effective in lowering the stroke risk among patients with nonvalvular atrial fibrillation, however, underdosing is frequently encountered. Researchers sought to report on clinician knowledge and patient or clinician preferences for DOAC dosing. An assessment of anticoagulation knowledge/preferences was offered to 240 clinicians and 343 patients with atrial fibrillation. Four hypothetical patient scenarios were used to test clinician knowledge of DOAC dosing. They asked patients and clinicians to grade the importance of 25 factors in anticoagulation decision making. All 4 scenarios were answered correctly by only 35.0% of clinicians with the label‐indicated dose. Stroke prevention and avoiding severe bleeding were ranked as very important to anticoagulation decision making by patients as well as clinicians. More frequently, patients vs clinicians ranked the ability to lower anticoagulation dose if required as very important (70.5% vs 43.6%). Overall findings revealed the presence of considerable knowledge gaps concerning DOAC dosing in clinicians managing patients with atrial fibrillation, as well as there were significant disparities in treatment dosing preferences between clinicians and patients.