Torgersen J, Taddei TH, Park LS, et al. - Since a substantially higher incidence of hepatocellular carcinoma (HCC) is seen among HIV-infected (HIV+) vs uninfected people, researchers intended to clarify whether HCC is morphologically distinct or more aggressive in the setting of HIV infection. Therefore, in the Veterans Aging Cohort Study, they assessed variations in tumor pathology in a cohort of HIV+ and uninfected patients with microscopically established HCC. To know Barcelona Clinic Liver Cancer stage, HCC treatment, and survival by HIV status, they reviewed pathology reports and medical records. This study included 873 patients with HCC (399 HIV+), of these, microscopically confirmed HCC was detected in 140 HIV+ and 178 uninfected persons. By HIV status, no differences were found in HCC tumor features or background hepatic parenchyma, yet findings revealed a link of HIV with poorer survival. These features were commonly omitted by pathology reports. In order to understand tumor features related to improved survival, it is necessary to perform a systematic assessment of HCC pathology by HIV status.