Lee RM, et al. - Among 27,151 pts (mean age was 68 yrs; 51% were male) with cholangiocarcinoma (CCA) of all sites and stages in the National Cancer Data Base (2004-14), the association of race/ethnicity and socioeconomic factors (SEF) with overall survival (OS) was determined. Non-Hispanic White (NH-W, 78%), non-Hispanic Black (NH-B, 8%), Asian (6%), and Hispanic (6%) groups were included. Income was defined as high (³$63,000) vs low ( < $63,000). Among participants, 56% had Medicare, 33% private insurance, 7% Medicaid, 4% were uninsured, and 67% had high income. Findings revealed that survival differences existed in CCA, however, they were not driven by race/ethnicity. Decreased OS was seen in non-privately insured and low-income pts as well as in those treated at non-academic centers and outside the Northeast. Factors related to decreased OS included male sex, older age, non-private insurance, low income, lower education, non-academic facility, location outside the Northeast, higher Charlson-Deyo score, worse grade, larger tumor size, and higher stage. Overall, worse outcomes result from decreased ability to access and afford care rather than biological differences amongst racial/ethnic groups.