Troy LK, Grainge C, Corte TJ, et al. - Researchers undertook this prospective, multicentre, diagnostic accuracy study, named the COLDICE, to confirm the diagnostic accuracy of transbronchial lung cryobiopsy (TBLC) vs surgical lung biopsy (SLB), in the context of the progressing use of TBLC in clinical practice as a less invasive biopsy technique. This inquiry was performed across 9 Australian tertiary hospitals. Eligibility criterion was the presence of interstitial lung disease, age between 18 and 80 years, need for histopathological assessment to help the diagnosis, following detailed baseline evaluation. Following screening at a centralised multidisciplinary discussion (MDD), the patients referred for lung biopsy had sequential TBLC and SLB under one anaesthetic. TBLC and SLB samples were each obtained from two separate ipsilateral lobes. Findings revealed that for both histopathological interpretation and MDD diagnoses, high levels of agreement between TBLC and SLB were evident. Especially reliable were TBLC MDD diagnoses made with high confidence, exhibiting excellent concordance with SLB MDD diagnoses. Based on findings, experts concluded that TBLC has clinical utility in interstitial lung disease diagnostic algorithms.