Tian MX, et al. - In this investigation, researchers developed and externally validated a novel prognostic score for postoperative combined hepatocellular-cholangiocarcinoma (CHC) patients. In the derivation cohort, 208 CHC subjects who had a liver resection, between 1999 and 2014, at Zhongshan Hospital of Fudan University were recruited. They also involved an external validation cohort of 101 patients at Mengchao Hepatobiliary Hospital of Fujian Medical University from 2003 to 2016. Five independent predictors connected with tumor recurrence have been recognized on multivariate analysis, including sex, γ-glutamyl transferase, macrovascular invasion, hilar lymphoid metastasis and adjuvant transcatheter arterial chemoembolization. In postoperative CHC patients, the developed and validated prediction score could be a simple and reliable method and assist clinicians to identify applicants who may benefit from future adjuvant therapies.