Baeza-Velasco C, et al. – Researchers investigated medication adherence in patients with a major depressive (MD) episode, and assessed sociodemographic, clinical, and psychosocial factors related to status adherence. Study participants included 370 patients at hospital admission who completed the Medication Adherence Rating Scale, a self-report measure of medication adherence in psychosis. Patients were then divided into groups of optimal and suboptimal adherence based on their scores. Only 29% of participants were found to be optimal adherents to their medication. The investigators observed a significantly higher severity of depression and more psychiatric hospitalizations, suicidal ideation, physical pain, negative medication side effects, and antecedents of emotional maltreatment among suboptimal adherents, who also had less favorable attitudes toward medication and were less in a relationship. In multivariate analyses, an increased probability of suboptimal adherence was attributed to depression severity, suicidal ideation, and physical pain.