Kuhrij LS, et al. - In this investigation involving 9,518 intravenous thrombolysis (IVT) treated patients from 75 hospitals, researchers analyzed patient- and clinical features correlated with (severely) extended DNT from a large nationwide registry, as well as identified factors related to a delay in onset-to-door time (ODT) and evaluated the impact of extended DNT on in-hospital mortality. The sample consisted of individuals receiving IVT in 2015 and 2016 registered in the Dutch Acute Stroke Audit. To examine the link between ODT and DNT, a linear model with natural spline was used. Data reported that median DNT was 26 min (IQR 20–37). Female gender and admission during off-hours were determinants linked to a higher probability of extended DNT. Short ODT was associated with longer DNT, while longer ODT was correlated with shorter DNT. Young age and admission to a comprehensive stroke center were correlated with severely extended DNT, which was related to in-hospital mortality. While DNT is short in the Netherlands compared with other countries, by focusing on specific subgroups, it may be possible to lower the DNT.