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Determinants of blood telomere length in antiretroviral treatment-naïve HIV-positive participants enrolled in the NEAT 001/ANRS 143 clinical trial

HIV Medicine Oct 04, 2019

Alejos B, Stella-Ascariz N, Montejano R, et al. - Factors associated with baseline blood telomere length were investigated in participants enrolled in NEAT 001/ANRS 143, a randomized, open-label trial comparing ritonavir-boosted darunavir (DRV/r) plus raltegravir with DRV/r plus tenofovir disoproxil fumarate/emtricitabine in antiretroviral therapy (ART)-naïve HIV-positive adults. Researchers conducted a cross-sectional study of 201 randomly selected participants who had stored samples available. Findings revealed shorter blood telomere length in correlation with both age and HIV RNA viral load among untreated persons living with HIV. HIV infection and age were thus suggested to have synergistic and independent influences upon immunosenescence.
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