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Detection of reduced retinal vessel density in eyes with geographic atrophy secondary to age-related macular degeneration using projection-resolved optical coherence tomography angiography

American Journal of Ophthalmology Sep 23, 2019

You QS, Wang J, Guo Y, et al. - Using projection-resolved optical coherence tomography angiography (PR-OCTA), researchers compared retinal vessel density in eyes with geographic atrophy (GA) secondary to age-related macular degeneration to age-matched healthy eyes. Participants in the study underwent macular 3×3-mm OCTA scans with spectral domain OCTA. For this investigation, 10 eyes with GA and 10 control eyes were analyzed. GA eyes have decreased retinal vessel density in superficial vascular complex, intermediate capillary plexus, and deep capillary plexus compared with controls. Data reported that loss is greatest within GA regions. In detecting inner retinal change in the eyes with GA, vessel density may be more sensitive than retinal layer thickness measurement.
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