Melin EO, et al. - Authors evaluated if depression in patients with type 1 diabetes (T1D) was related to high circulating galectin-3, controlling for metabolic variables, s-creatinine, lifestyle factors, medication, and cardiovascular complications. This was the first study to demonstrate a relationship between depression and galectin-3. The only explored parameter associated with high circulating galectin-3 levels in 283 T1D patients was depression. Findings suggested a probable contribution of high galectin-3 levels to the increased risk for Alzheimer's disease, cardiovascular and all-cause mortality observed in persons with depression. Potentially, the prognosis for patients with high galectin-3 levels could be improved with treatment targeting galactin-3 levels in the future.