Shi W, et al. - In pancreatic cancer (PC) patients with isolated locoregional recurrence following radical resection, researchers assessed the safety and effectiveness of definitive chemoradiotherapy and salvage chemotherapy and the factors associated with tumor response. They included patients with isolated locoregional recurrent PC treated with definitive chemoradiotherapy and salvage chemotherapy either before, at the same time as, or after radiotherapy between 2012 and 2017 was conducted. Among 31 participants, median interval from the resection of primary PC to the diagnosis of the locoregional recurrence (DFI) was 7.4 months. Median overall survival (OS) from the start of RT was 23.6 months; freedom from locoregional progression rates from the start of RT was 12.0 months. A favorable OS was significantly linked with DFI >6 months. Acute and late toxicity of grade 3 occurred in 3 patients and 1 patient, respectively, while no grade 4 toxicity or higher was seen. Definitive chemoradiotherapy and salvage chemotherapy was feasible and tolerable as a treatment strategy for patients with isolated locoregional recurrence after radical resection of primary PC.