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Decreased clinical pregnancy and live birth rates after short interval from delivery to subsequent assisted reproductive treatment cycle

Human Reproduction Jun 30, 2018

Quinn MM, et al. - Researchers investigated whether the interval from delivery to initiation of a subsequent ART treatment cycle impact clinical pregnancy or live birth rates. They found a decreased likelihood of clinical pregnancy and live birth related to an interval from delivery to treatment start of <6 months or ≥24 months.

Methods

  • Researchers performed this retrospective analysis of the Society for Assisted Reproductive Technology Clinical Outcome Reporting System (SARTCORS) cohort containing 61,686 ART cycles from 2004 to 2013.
  • They calculated the delivery-to-cycle interval (DCI) for patients from SARTCORS with a history of live birth from ART who returned to the same clinic for a first subsequent treatment cycle.
  • Using generalized linear models, they investigated the risk of clinical pregnancy and live birth by DCI with subsequent adjustment for factors related to outcomes of interest.
  • From each model, they generated predicted probabilities of clinical pregnancy and live birth.

Results

  • They found a DCI of <6 months vs a DCI of 12 to <18 months was associated with a 5.6% reduction in probability of clinical pregnancy (40.1 ± 1.9 vs 45.7 ± 0.6%, P=0.009) and 6.8% reduction in live birth (31.6 ± 1.7 vs 38.4 ± 0.6%, P=0.001) per cycle start.
  • Findings revealed a DCI of ≥24 months vs 12 to <18 months was related to a 5.1% reduction in probability of clinical pregnancy (40.6 ± 0.5 vs 45.7 ± 0.6%, P < 0.001) and 5.7% reduction in live birth (32.7 ± 0.5 vs 38.4 ± 0.6%, P < 0.001).

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