Decreased absolute lymphocyte count and increased neutrophil/lymphocyte ratio with immune checkpoint inhibitor–associated myocarditis
Journal of the American Heart Association Dec 05, 2020
Drobni ZD, Zafar A, Zubiri L, et al. - Given that myocarditis due to immune checkpoint inhibitor (ICI) treatment represents a potentially fatal immune‐related adverse event, researchers focused on defining the role of absolute lymphocyte count (ALC) and neutrophil/lymphocyte ratio (NLR) in ICI‐associated myocarditis in this case control analysis including 55 patients with ICI myocarditis and 55 controls without any post‐ICI immune‐related adverse events. Electronic medical records were used to retrospectively extract data on the covariates. According to the findings, a decrease in ALC and an increment in NLR was observed with ICI myocarditis. A greater reduction in ALC or rise in NLR was identified to be related to subsequent major adverse cardiac events.
-
Exclusive Write-ups & Webinars by KOLs
-
Daily Quiz by specialty
-
Paid Market Research Surveys
-
Case discussions, News & Journals' summaries