Otaki Y, et al. - Given the correlation of low-density lipoprotein cholesterol (LDL-C) reduction with a decrease in noncalcified plaque (NCP), researchers examined how specific components of noncalcified plaque (NCP) are impacted by LDL-C reduction in 154 patients. Serial CT angiography (CTA) was performed on patients (118 men, 60 ± 10 years, interval 4 ± 2 years) with a baseline LDL-C≥70 mg/dl. Quantification of the plaque components based on CT attenuation in Hounsfield units (HU) was done using semi-automated software, with 30-75 was low attenuation plaque (LAP), 76–130 was medium-low attenuation plaque (MLAP), 131–350 was medium attenuation plaque (MAP), and >350 was calcified plaque (CP). Outcomes revealed a reduction in all components of NCP in correlation with the decrease in LDL-C. Changes of coronary plaque on CTA over time could be optimally assessed by measuring a change in total NCP volume.