Checchi M, et al. - Data reporting anogenital warts (AGW) diagnoses in sexual health clinics (SHCs) in England to the end of 2017, including diagnoses among birth cohorts offered the quadrivalent vaccine, were presented. Further, they tested for trends over time of diagnoses of AGW in young females, heterosexual males, and men who have sex with men (MSM) between the ages of 15 and 24 years during both bivalent (2009 to 2013) and quadrivalent (2014 to 2017) vaccine time periods using Poisson regression. Strong evidence suggested a decreasing trend in the rate of AGW diagnoses at SHC among females aged 15–17 years and same aged heterosexual males between 2014 and 2017. Less clear reductions in the incidence of AGW diagnoses in MSM aged 15–17 years were evident. Since the introduction of a high-coverage HPV vaccination programme using the bivalent vaccine, moderate, unexpected declines in AGW are observed. These declines are expected to be followed by much larger declines among females offered the quadrivalent vaccine and same-aged heterosexual males.